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91.
G. R. Q. VEALL 《Anaesthesia》1994,49(5):409-410
92.
电针心经对心肌缺血性家兔心力环面积的影响 总被引:1,自引:0,他引:1
以心力环面积为指标,静脉滴注垂体后叶素造成家兔心肌缺血动物模型,结果表明,电针心经地心脏功能的调节作用比电针肺经显著,有相对特异性,说明心经作为一条经脉,与心脏机能活动有密切关系。 相似文献
93.
冠心病行为模式与心理状态的相关性探讨 总被引:8,自引:1,他引:7
目的为探讨A型行为在冠心病(CoronaryHeartDisease,CHD)中的作用及与心理状态的相关性。方法对114例CHD及37例非CHD应用心理测验方法对照调查。结果发现A型行为的人易患CHD。CHDA型行为者在焦虑、抑郁、人际关系、认识、敌对性症状因子分较CHD非A型行为者有明显增高。CHD非A型行为者也具有一些特有的心理症状。结论CHD病人的行为模式与病后的某些心理表现呈正相关。 相似文献
94.
采用配对病例对照研究,探讨先心病与柯萨奇病毒B3、B4感染的关系,结果显示:病例组与对照组患儿CVB3、CVB4.IgG抗体阳性率分别为59.3%、54.3%和53.6%、45.7%,差异天显著性(P值均>0.05);经单因素和多因素回归分析均未发现CVB3、CVB4感染与先心病有病因学联系(P>0.05) 相似文献
95.
Martin Ungerer Michael Böhm Robert H. G. Schwinger Erland Erdmann 《Naunyn-Schmiedeberg's archives of pharmacology》1990,341(6):577-585
Summary The effects of the new inotropic agents saterinone, sulmazole, UD-CG 212.C1 and milrinone at A1 adenosine receptors and m-cholinoceptors were evaluated in human myocardium from patients with heart failure. At A1 adenosine receptors, all compounds inhibited 3H-DPCPX-binding to ventricular membrane preparations at micromolar concentrations. As judged from the Ki-values, the rank order of potency was saterinone > sulmazole > UD-CG 212.C1 > milrinone. The new inotropic agents also displaced the binding of 3H-QNB at m-cholinoceptors. Except for saterinone, the concentration ranges of mean Ki-values were considerably higher at m-cholinoceptors than at A1 adenosine receptors. The rank order of potency was saterinone > sulmazole > UD-CG 212.Cl > milrinone. Competition of the A1 adenosine receptor agonist R-PIA to 3H-DPCPX-binding showed a biphasic curve with a shallow slope (Hill coefficient nH = 0.63) and revealed two affinity states of the A1 adenosine receptor. In the presence of guanine nucleotides [Gpp(NH)p], the competition curve showed one low affinity class of binding sites and was shifted to the right. In contrast, the competition curves of the new inotropic agents were characterized by a monophasic, steeper slope (mean Hill coefficient nH = 0.98). Guanine nucleotides had no effect. Similar results were obtained with saterinone and carbachol at m-cholinoceptors. Competition with carbachol revealed three affinity states of the m-cholinoceptor, the superhigh affinity binding was reversed by Gpp(NH)p. Competition with saterinone revealed one class of binding sites which was not influenced by Gpp(NH)p. Accordingly, in isolated, electrically driven human atrial trabeculae, the negative inotropic effect of adenosine was antagonized concentration-dependently by saterinone, sulmazole and UD-CG 212.Cl. Similarly the negative inotropic effect of carbachol was antagonized concentration-dependently by saterinone. It is concluded that the new inotropic agents bind to A1 adenosine receptors and that their interaction is of antagonist nature. This mechanism might contribute to their capacity to enhance force of contraction by stimulation of cAMP-formation in addition to phosphodiesterase inhibition. The effects of saterinone may be partially due to antagonism at m-cholinoceptors. This is presumably not the case with the other inotropic agents studied given their low affinity for this receptor.Send offprint requests to M. Böhm at the above addressSupported by the Deutsche Forschungsgemeinschaft 相似文献
96.
Bicarbon valve - European multicenter clinical evaluation 总被引:1,自引:0,他引:1
J.B Borman W.G.B Brands L Camilleri M Cotrufo W Daenen I Gandjbakhch C Infantes A Khayat F Laborde A Pellegrini A Piwnica B Reichart R Sharony R Walesby H Warembourg 《European journal of cardio-thoracic surgery》1998,13(6):685-693
Objective: Fifteen collaborating centers in eight countries present their pooled experience with the new Bicarbon™ bileaflet valve. Methods: Between 4/90 and 4/96, 1351 patients, 806 males and 545 females, aged 10 to 83, mean 58.4±12.4, underwent valve implantation. Operations: AVR, 726; MVR, 475; DVR, 150. Additional procedures: CABG, 211; TV repair, 64; other, 152. Results: Mortality: 67 early (seven valve related) and 56 late (40 valve related). Valve thrombosis: six obstructive, three non-obstructive; embolism: nine major cerebral, 37 other. Major bleeding: 29. Hemolysis: two clinically significant. Non-structural dysfunction: 24 paravalvular leaks, one leaflet interference. No structural failure! Endocarditis: 24. Reoperation 48: 22 non-structural dysfunctions, 14 endocarditis, seven thrombosis and embolism, five other. Estimated 5-year freedom from valve-related deaths is 97.2% for AVR and 92.4% for MVR; 4-year freedom from valve related deaths for DVR is 90.5%. Mean calculated NYHA improvement is 1.24. Conclusions: The Bicarbon mechanical prosthesis is well designed, durable, has good hemodynamic features and an acceptably low incidence of complications. 相似文献
97.
T. Rechlin 《Intensive care medicine》1995,21(7):598-601
Objective Since intoxication with tricyclic antidepressants is common, a supplementary screening method for differentiation between therapeutic and supratherapeutic ranges would be a valuable diagnositc tool, particularly in delirious and unconscious patientsSetting 109 patients treated with amitriptyline, 8 patients treated with doxepin, 10 patients treated with clozapine, and 72 normal control subjects matched for age and sex were tested for heart rate variability while resting.Results Considering time and frequency derived measures, which are rather independent of heart rate, the patients showed significantly decreased heart rate variability parameters (p<0.0001), as compared with the normal subjects. Of the patients presenting delirious symptoms 6 showed coefficients of variation more than 4 standard deviations below the mean control value.Conclusions As heart rate variability can be easily calculated, this measurement is suggested as a useful tool to quickly exclude or support the diagnosis of chronic intoxication with tricyclic antidepressants or clozapine. 相似文献
98.
Fear and the startle reflex: Blink modulation and autonomic response patterns in animal and mutilation fearful subjects 总被引:7,自引:1,他引:6
The present study was designed to examine the pattern of startle reflex modulation and autonomic responses for individuals high in animal or blood-injury fear when viewing pictures of their feared objects. Sixteen individuals in each fear group and 16 low-fear control individuals viewed 32 color slides depicting fear-relevant, unpleasant but fear-unrelated, neutral, and pleasant scenes. Free viewing times were assessed in a second phase of the procedure as an index of avoidance behavior. Exposure to pictures of feared objects resulted in a consistent startle reflex potentiation and behavioral avoidance in both fear groups. This activation of the basic aversive system was independent of the autonomic pattern of the fear responses, which differed for the high-fear groups. These results suggest that the probe startle response indexes the organism's basic motivational disposition and add new information to the assessment of fear. 相似文献
99.
G. Aernout Somsen Ernst E. van der Wall Bob van Vlies Judocus J. J. Borm Eric A. van Royen 《The International Journal of Cardiac Imaging》1996,12(4):305-310
In patients with chronic heart failure, increased sympathetic activity and cardiac sympathetic neuronal dysfunction are present and have been related to unfavourable clinical outcome. Modification of these alterations with the objective to improve prognosis has become an important aim of pharmacological therapy for these patients. A noninvasive technique to assess sympathetic neuronal function at the cardiac level may be valuable in evaluating newly developed therapeutic strategies. 123-iodine metaiodobenzylguanidine can be used visualize cardiac sympathetic nerve function and activity. Single photon emission computerized tomographic is preferred to planar scintigraphy since it does not depend on superposition of other anatomical structures and may allow assessment of regional cardiac 123-iodine metaiodobenzylguanidine uptake. Although the quantitation of cardiac uptake in these tomographic images has several limitations, the use of the left ventricular cavity as a reference, calibrated by the 123-iodine activity in a blood sample drawn at the time of acquisition, may have clinical applications, with respect to the evaluation of therapeutical intervention in patients with heart failure.Abbreviations BS
blood sample
- CD
count density
- dP/dt
change in pressure over time
- [123I]
123-iodine
- Km
affinity constant
- MIBG
metaiodobenzylguanidine
- MBq
mega Bequerel
- SPECT
single photon emission computerized tomography
- Vm
capacity constant 相似文献
100.
目的:为了深讨心肌细胞内钙离子浓度的变化与心力衰竭发生的关系。方法:原子吸收分光技术测定红细胞内外Ca2+含量。我们对住院的56例心力衰竭患儿进行了红细胞内及血浆钙离子浓度的测定,并与30例正常小儿对照。结果:心衰患儿红细胞内Ca2+浓度明显升高,血浆Ca2+浓度降低,与对照组相比有非常显著性差异(P<0.001)。其升高程度与心衰呈正相关(r=0.63,P<0.01),即心衰越重,心功能越差,红细胞内Ca2+浓度升高亦越明显。而当心衰纠正,心功能恢复后,红细胞内Ca2+浓度则明显下降,血浆Ca2+浓度也恢复正常。而不同病因所致的心衰,其间红细胞内Ca2+浓度升高程度无明显差异。结论:提示钙离子参与了心力衰竭的发生与发展。 相似文献